Spider-Man: Far from Home (2019)
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We only know of 4 associates (calling 'Flash' a friend is a real stretch) of his who were affected by the snap; Flash, MJ, Ned, and Aunt May (if we add in Nick Fury then we also add in Tony Stark, Maria Hill, etc. so let's keep it to people immediately around him). Most of the other characters are unknown with the exception of Brad Davis (Peter and Ned talk about how strange it is to see him older), Mr. Dell (whose wife faked being wiped out by the snap in order to get away from him), and Happy who grew a beard during the period.
That's relatively close to 50%. What's more, because of statistical clustering there would be plenty of times when the number of people someone knew would have either a disproportionately high number of people affected or unaffected by the snap. If you throw 10 coins in the air the odds that you will see something 'suspicious' (3 or fewer heads or tails) is about 35%. Edit