Originally, one episode had a scene where Fry pulls down his pants and moons the business magnate Mom (of Mom's Friendly Robots). Her original dialogue was, "You call that an anus?", but it only appeared in closed captioning and was redubbed with "You call that a pressed ham?".
Cartoon Network has censored the Professor's favorite expletive, "Sweet Zombie Jesus" on at least two occasions, removing the Jesus.